Demax (Generic Namenda) Memantine

1. What is DEMAX and what is it used for?

• DEMAX 20 mg film tablets are available in blister packs of 28 and 84 tablets. It is a pink, oval biconvex film-coated tablet.

• Memantine belongs to the anti-dementia drug group and is an NMDA receptor antagonist. Memory loss in Alzheimer’s disease is due to impaired message signals in the brain. There are N-methyl-D-aspartate (NMDA) receptors in the brain, which are responsible for transmitting nerve signals that are important in learning and memory. Memantine improves the transmission of nerve signals and memory by affecting NMDA receptors.

• DEMAX is used in the following conditions. It is used in the treatment of moderate and severe Alzheimer’s disease.

2.How to use DEMAX?

Instructions for proper use and dose/frequency of administration

During the first 3 weeks of treatment, the 20 mg dose reached by gradually increasing the DEMAX dose is the recommended daily treatment dose. Take one tablet a day.

Week 1 (1-7 days):

During the first week, take 5 mg memantine once a day (1 DEMAX 5 mg Film Tablet).

2. Week (7-14 days):

Take 10 mg memantine once a day for the second week (1 DEMAX 10 mg Film Tablet)

3. Week (14-21 days):

Take 15 mg memantine once a day for the third week (1 DEMAX 15 mg Film Tablet)

4. Week:

From the fourth week, continue the treatment with 20 mg memantine once a day (1 DEMAX 20 mg Film Tablet or 2 DEMAX 10 mg Film Tablets)

Follow-up dose:

The recommended daily dose is 20 mg.

Use in the elderly

Application route and method

Use orally once a day. The tablets should be swallowed with some water.

You can use the tablet regardless of food intake (either on an empty or full stomach).

Special use cases

If you have kidney failure, your doctor will determine the dose you need. Your doctor will monitor your kidney functions at regular intervals.

Liver failure

No dose adjustment is required in patients with mild or moderate hepatic dysfunction (Child-Plugh A and Child-Plough B). No data are available on the use of mementin in patients with severe hepatic impairment. The use of DEMAX is not recommended in these patients.

If you have the impression that the effect of DEMAX is too strong or too weak, talk to your doctor or pharmacist.

3. What are the possible side effects?

Like all medicines, there may be side effects in people who are sensitive to the substances contained in DEMAX.

Side effects of DEMAX are generally mild to moderate. Common (1-10 out of 100 people):

Headache, somnolence, constipation, drowsiness and high blood pressure Uncommon (1-10 in 1000 people)\

Fatigue, fungal infection, confusion, hallucinations, vomiting, abnormal gait, heart attack, venous occlusion (deep vein thrombosis)

Very rare (less than 1 in 10,000 people): Seizure

Not known (cannot be estimated from the available data): Pancreatitis and psychotic reactions

Depression, suicidal ideation and suicide develop due to Alzheimer’s disease. These events have been reported in patients treated with memantine.