Divina 21 Tabs Estradiol

1. What is DIVINA and what is it used for?

DIVINA is a combined hormone preparation for two cycles of hormone replacement therapy (HRT). It contains white and blue tablets in a box. The tablets contain estrogen and progestagen.

Estrogen and progesterone production in the body begins to decrease with menopause. Divina replaces these hormones and prevents or improves the symptoms caused by the deficiency of these hormones. Divina mimics the menstrual cycle, so that the initial estrogen period (11 days; white tablets) is followed by a combined estrogen-progesterone period (10 days; blue tablets) and withdrawal bleeding usually occurs in the next week.

Based on these, Divina;

– Hot flashes, night sweats, dryness in the vagina, etc., which can be seen in many women in menopause. in improving menopausal symptoms such as

– In the prevention of osteoporosis (thinning of the bones),

– In menstrual bleeding irregularities,

– It is used when the female sex hormone needs to be “replaced” (such as surgical removal of the ovaries).

Divina causes regular monthly cycles to return in postmenopausal women.

Divina Tablet is not a contraceptive. Experience with women over 65 years of age is limited.

2.How to use DIVINA?

Instructions for proper use and dose/frequency of administration

DIVINA; since it is a drug that mimics the dual-acting human monthly bleeding cycle; Take 11 days white tablet once a day (estrogen phase) and 10 days blue tablet once a day (combined estrogen and progestin phase).

After 21 days of treatment, take a 7-day break (medication-free period).

If you are postmenopausal, you can start treatment immediately.

If you have not reached menopause, you can start using DIVINA on the 5th day of your monthly bleeding. It is better to take the tablet in the evening.

3. What are the possible side effects?

Like all medicines, there may be side effects in people who are sensitive to the substances contained in DIVINA.

If any of the following occur, stop using DIVINA and IMMEDIATELY inform your doctor or go to the nearest hospital emergency department:

• Swelling of the hands, feet, wrists, face, lips, or especially swelling of the mouth or throat that makes it difficult to swallow or breathe.

• A palpable mass in the breast

• Abnormal bleeding in the vagina

• Abnormal mass or abnormal growth in the uterus

• Discomfort in your heart

• Paralysis

• Pain observed due to the problem in the blood flow in the legs

• Venous thrombosis (blood clot in the vein or heart)

These are all very serious side effects.

If you have any of these, you have a serious allergy to DIVINA. You may need emergency medical attention or hospitalization.

All of these very serious side effects are very rare.

Tell your doctor if you notice any of the following:

Very common side effects:

• Breast tenderness

• Nausea,

• Edema

• Headache

• Tiredness

• Personality changes

• Change in sexual desire

• Weight gain

• intermediate bleeding

rare side effects

• Migraine

• Visual disorders

• Changes in liver enzyme concentrations and coagulation (blood coagulation) factors

These are mild side effects of DIVINA.