Imuran Tablets azathioprine

1. What is IMURAN and what is it used for?

IMURAN is sold as 100 tablets of 50 mg in blisters.

IMURAN is a member of the group called immunosuppressive drugs, immunosuppressive drugs weaken the immune system, but this is a desired effect in organ transplant patients or in certain diseases (autoimmune diseases) where the immune system damages its own body cells.

IMURAN is used in the following conditions:

• In order to increase the acceptability of the transplanted organ in organ transplant patients

• To treat some diseases (autoimmune diseases) in which the immune system damages its own body cells.

The following are autoimmune diseases for which IMURAN is used:

• Severe rheumatoid arthritis (swelling and pain in the joints due to inflammation)

Dermatomyositis/polymyositis (inflammatory diseases of unknown cause seen in skeletal muscle, skin rashes are included in the findings, unlike polymyositis in dermatomyositis)

• Autoimmune chronic active hepatitis (an autoimmune disease that usually occurs in young women with fever, joint pain and skin rash)

• Pemphigus vulgaris (an autoimmune disease of unknown cause characterized by the formation of bullae on the skin and mucous membranes)

• Polyarteritis nodosa (vascular disease with inflammation of small arteries sometimes accompanied by fever)

• Autoimmune hemolytic anemia (a disease in which the immune system cells damage blood cells called red blood cells)

• Chronic refractory idiopathic thrombocytopenic purpura (autoimmune disease that develops with a decrease in the number of cells called thrombocytopenia in the blood that provide clotting and bleeding on the mucous membranes)

2. How to use IMURAN?

Instructions for proper use and dose/frequency of administration

Adult use

In organ transplantation: Up to 5 mg/kg/day of IMURAN can be given, usually on the first day of treatment. The maintenance dose is between 1-4 mg/kg/day.

Because of the risk of transplant rejection, IMURAN therapy should be administered indefinitely, even at very low doses.

Other diseases: The usual starting dose is 1-3 mg/kg/day. Depending on your response to the treatment, your doctor may increase the dose of your medication from less than 1 mg/kg/day to 3 mg/kg/day.

Application route and method

Take IMURAN tablets with some water.

Different age groups:

Use in children

In the treatment of organ transplantation and other diseases: The dose and method of administration are the same as in adults.

Use in the elderly

Your doctor will adjust the dose of your medicine according to your general condition.

Special use cases:

Kidney and liver failure:

Your doctor will adjust the dose of your medicine according to the condition of your kidney and liver disease. Unless your doctor recommends otherwise follow these instructions.

Do not forget to take your medicine on time.

Your doctor will tell you how long your treatment with IMURAN will last. Do not stop your treatment early because you will not get the desired result.

If you have the impression that the effect of IMURAN is too strong or weak, talk to your doctor or pharmacist.

3. What are the possible side effects?

Like all medicines, there may be side effects in people who are sensitive to the substances contained in IMURAN.

If any of the following occur, stop using IMURAN and IMMEDIATELY inform your doctor or go to the nearest hospital emergency department:

• Hypersensitivity reactions:

– General tiredness, dizziness, nausea, vomiting or diarrhoea.

– High fever, chills or chills

– Skin rash or skin rash

– Pain in muscles and joints

– Change in urine color and amount (kidney problems)

– Dizziness, confusion, drowsiness caused by low blood pressure

• Easy bruising or unusual bleeding

• High fever or other signs of infection

• Severe fatigue

• Lumps in the body

• Changes in the skin such as blistering, peeling

• Deterioration of general health status

These are all very serious side effects.

If you have one of these, you may need emergency medical attention or hospitalization.

Common (affects less than 1 in 10 people) *

– Low platelet level that will cause bruising and easy bleeding

Uncommon (affects less than 1 in 100 people)

– Decreased levels of red blood cells that can make you feel tired, have a headache, have shortness of breath during exercise, look dizzy and pale.

– Inflammation of the pancreas that will cause upper stomach pain, nausea and vomiting

– Liver problems that can cause dark stools, dark urine, itching and yellowing of the skin and eyes.

Rare (affects less than 1 in 1000 people)

– Weakness, tiredness, pallor, headache, pain in the tongue, shortness of breath, bruising, or problems with the blood and bone marrow that can cause an infection

Intestinal problems that can cause diarrhoea, abdominal pain, constipation, nausea and vomiting